egfr kinase inhibitor 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63648	EGFR kinase inhibitor 1
	EGFR kinase inhibitor 1 is a potent inhibitor of EGFR that acts on WT (IC50: 37 nM), l885R/T790M (IC50: 1.7 nM), and L858R/T790M/C797S (IC50>300 nM). EGFR kinase inhibitor 1 is capable of blocking the cell cycle in G0/G1...
T9865	Almonertinib mesylate		EGFR
	Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer st...		EGFR
T4015	HG-14-10-04		ALK
	HG-14-10-04 is a potent and specific ALK inhibitor.		ALK
T4296	MTX-211	MTX 211	EGFR , PI3K
	MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.		EGFR , PI3K
T22396	PF-6274484	PF 6274484	EGFR
	PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and ...		EGFR
T1181	Gefitinib	ZD1839	EGFR , Tyrosine Kinases , Autophagy
	Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell...		EGFR , Tyrosine Kinases , Autophagy
T1985	WHI-P154	Jak3 inhibitor ii	Apoptosis , EGFR , VEGFR , JAK , Src
	WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.		Apoptosis , EGFR , VEGFR , JAK , Src
T3024	Avitinib	AC0010	EGFR , JAK , BTK
	Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administrat...		EGFR , JAK , BTK
T39275	Befotertinib	D-0316,Befotertinib	EGFR
	Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.		EGFR
T2851	Daphnetin	7,8-Dihydroxycoumarin,Daphnetol	EGFR , PKA , PKC , Parasite , Autophagy
	Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...		EGFR , PKA , PKC , Parasite , Autophagy
T6712	Tyrphostin AG 879	AG 879	Apoptosis , EGFR , Trk receptor , HER , PDGFR
	Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.		Apoptosis , EGFR , Trk receptor , HER , PDGFR
T21312	Afatinib	Afatinib free base,BIBW 2992	EGFR , Autophagy
	Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively).		EGFR , Autophagy
T4185	Lavendustin C	HDBA,NSC 666251	CaMK , EGFR , Tyrosinase , Src
	lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.		CaMK , EGFR , Tyrosinase , Src
T4205	AG-494	Tyrphostin AG-494,AG 494,Tyrphostin B48	EGFR , CDK
	AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.		EGFR , CDK
T2600	AG490	Zinc02557947,Tyrphostin AG 490,AG 490,AG-490,Tyrphostin B42	EGFR , JAK , STAT , Autophagy
	AG490 (Tyrphostin B42) is an inhibitor of EGFR (IC50: 0.1 μM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src.		EGFR , JAK , STAT , Autophagy
T1773	Afatinib Dimaleate	BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate	EGFR , HER , Autophagy
	Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act...		EGFR , HER , Autophagy
T9304	(S)-Sunvozertinib	N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008	EGFR , HER
	(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.		EGFR , HER
T5524	Aurora kinase inhibitor-3	Aurora Kinase Inhibitor III	Aurora Kinase
	Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.		Aurora Kinase
T14692	BMX-IN-1	BMX kinase inhibitor	BTK
	BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 ...		BTK
T60108	PDGFR Tyrosine Kinase Inhibitor III	PDGF Receptor Tyrosine Kinase Inhibitor III	PDGFR
	PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGF...		PDGFR